Lipopeptides—peptides covalently linked to lipid moieties—represent a versatile class of amphiphilic molecules whose structural features allow them to self-assemble, interact with membranes, and modulate interfacial phenomena. Here, we explore the nature of lipopeptides, survey their structural diversity and physicochemical properties, and discuss novel research-domain implications beyond classical antimicrobial roles. We go on to highlight how lipopeptides may serve as tools...